A 43-year-old woman has blood pressure of 160/90 mmHg and shows Na+=140mmol/L, K+=3.1mmol/L. What is the most likely diagnosis?

The clinical scenario presented describes a 43-year-old woman with hypertension and an electrolyte imbalance characterized by normal sodium levels and low potassium levels. This combination of findings is strongly indicative of primary hyperaldosteronism, commonly known as Conn's syndrome.

In Conn's syndrome, excessive production of aldosterone from the adrenal glands leads to sodium retention, which can cause hypertension due to increased blood volume. More importantly, aldosterone facilitates the renal excretion of potassium, which explains the observed hypokalemia (low potassium levels) in this patient. The presence of these symptoms—hypertension coupled with low potassium—forms a classic presentation for Conn's syndrome.

While Cushing's syndrome can also lead to hypertension and occasionally hypokalemia, it typically presents with additional signs such as obesity, moon facies, and skin changes that are not indicated in this scenario. Hyperparathyroidism primarily affects calcium metabolism and would not commonly present with low potassium and elevated blood pressure. Renal disease can cause hypertension and electrolyte imbalances, but it usually results in a different pattern of potassium levels and would be less specifically connected to the findings present here compared to Conn's syndrome.

Thus, the combination of hypertension and low potassium levels aligns well with Conn's syndrome, making it