What syndrome is associated with excessive secretion of growth hormone in adults?

Acromegaly is a disorder that occurs due to excessive secretion of growth hormone (GH), typically resulting from a benign tumor of the pituitary gland known as an adenoma. In adults, the excess growth hormone leads to the enlargement of bones and tissues, particularly affecting the hands, feet, and face. This condition develops slowly, and individuals may not notice changes until significant growth has occurred. Symptoms can also include joint pain, increased sweating, and changes in facial features, among others.

The other conditions listed do not primarily involve the secretion of growth hormone. Cushing's syndrome is characterized by excessive cortisol production and leads to different symptoms such as weight gain, hypertension, and glucose intolerance. Graves' disease is an autoimmune condition responsible for hyperthyroidism, which does not involve growth hormone at all. Addison's disease is associated with insufficient cortisol production, leading to fatigue, weight loss, and low blood pressure, rather than excess growth hormone. Thus, acromegaly stands out as the only condition directly related to excessive growth hormone secretion in adults.