Which of the following is a common symptom of Addison's disease?

In Addison's disease, which is a form of primary adrenal insufficiency, one of the hallmark symptoms is weight loss. This occurs due to a deficiency in adrenocortical hormones, particularly cortisol and aldosterone. Cortisol plays a crucial role in metabolism and energy regulation, so its deficiency can lead to a decreased ability to metabolize nutrients, resulting in unintended weight loss. Additionally, the lack of aldosterone affects sodium and water retention, which can further contribute to weight loss.

The other symptoms associated with Addison's disease include fatigue, muscle weakness, low blood pressure, and changes in skin pigmentation, but weight loss is particularly prominent. In contrast, weight gain and increased appetite are typically not associated with this condition, as the body's metabolic function is impaired. Hot flashes are also not characteristic of Addison's disease. Understanding these symptoms is key in diagnosing and managing adrenal insufficiency effectively.